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Regenerative Medicine Could Soon Transform Treatment of Musculoskeletal Conditions
UCSF’s Brian Feeley, MD, and Xuhui Liu, MD, in collaboration with Kevin Healy, PhD, received a $1.2 million grant for their lab from the California Institute of Regenerative Medicine to continue pursuing their translational research in regenerative medicine.
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Custom Cochlear Implant Programming Shows Promise for Improving Music Perception
A new clinical trial underway at UCSF, High-Resolution CT-Guided Cochlear Implant Programming, aims to improve speech and music perception for cochlear implant (CI) users.
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3D Facial Analysis Shows Biologic Basis for Gender-Affirming Surgery
In order to validate surgical decisions for gender-affirming facial surgery, researchers from the UC San Francisco and the University of Calgary set out to quantify the effect of sex on adult facial size and shape through an analysis of three-dimensional (3D) facial surface images.
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New Laryngopharyngeal Sensitivity Test Could Transform Patient Care
UCSF researchers have developed a first-of-its-kind technique to objectively evaluate laryngopharyngeal sensation.
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Novel Technique Improves Skin Color Match in Facial Reconstruction
A new procedure developed by UCSF facial plastic surgeons provides patients undergoing microvascular facial reconstruction with a more accurate skin color match than was previously possible.
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UCSF Deploys Innovative Data System to Integrate Research and Care
UC San Francisco (UCSF), in collaboration with the Quantum Leap Healthcare Collaborative (QLHC) and the U.S. Food and Drug Administration (FDA) has developed the OneSource system to seamlessly integrate clinical care and research data.
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UCSF’s Dr. Mitchel Berger on the Cancer Moonshot Relaunch
On Feb. 2, 2022, Mitchel Berger, MD, neurosurgeon and director of the UCSF Brain Tumor Center, attended the relaunch of the White House’s Cancer Moonshot initiative at the invitation of President Joe Biden and Dr. Jill Biden.
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UCSF Neurologist to Receive Prestigious Scientific Award
Stephen L. Hauser, MD, Professor of Neurology and Director of the UCSF Weill Institute for Neurosciences, has been chosen by the American Brain Foundation (ABF) to receive its second annual Scientific Breakthrough Award. Hauser is being honored for his career-long commitment to advancing the understanding of the genetic basis, immune mechanisms and treatment of multiple sclerosis (MS).
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How to Assign Malignancy Risk to Adnexal Masses Based on Imaging Features
Adoption of the Ovarian-Adnexal Reporting and Data System (O-RADS) by UCSF radiologists, gynecologists and gynecologic oncologists has reduced ambiguity in ultrasound (US) and MRI reporting of ovarian and adnexal lesions, with enormous potential to improve patient outcomes.
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Physician Referral Guide - Focused Ultrasound for Essential Tremor
Essential tremor is the most common movement disorder, affecting an estimated 10 million Americans. Using MR guidance, focused ultrasound can alleviate essential tremor by targeting the ventral intermediate nucleus (Vim) of the thalamus.
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Bladder Cancer Home Test Reduced Need for Cystoscopy During COVID-19
A study led by UCSF urologic cancer surgeons Sima Porten, MD, MPH, and Maxwell Meng, MD, found that use of a home urine test during the COVID-19 pandemic decreased the frequency of surveillance cystoscopy for patients with a history of non-muscle invasive bladder cancer (NMIBC).
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Using AI in Electrocardiogram Analysis Can Improve Diagnosis and Treatment of Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden death in adolescents and initial detection is often difficult. A new UCSF study finds that Artificial Intelligence-enhanced (AI)-Electrocardiograms (ECG) may help identify the condition in its earliest stages and monitor important disease-related changes over time.
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Positive Patient Outcomes With Minimally Invasive Skull Base Surgery: UCSF Case Studies
The following case studies describe how Ezequiel (Eze) Goldschmidt, MD, PhD, and the UCSF Brain Tumor Center team used the EEA to successfully remove different types of tumors, including a pituitary adenoma, a craniopharyngioma, an epidermoid cyst and a chondrosarcoma.
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Deep Brain Stimulation for Medication-Resistant Dystonia: A UCSF Case Study
A 10-year-old boy developed left-foot inversion, which made it difficult for him to walk. He subsequently developed a tremor in his right arm, and then his neck and trunk began to twist. He was seen by several practitioners but did not get a correct diagnosis. At age 17, he was referred to the UCSF Movement Disorders and Neuromodulation Center.
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Immune Cells Leave Fingerprints on Tumors Metastasized to the Brain Offering Clues to Future Therapies
Using data from over 100,000 malignant and non-malignant cells from 15 human brain metastases, UCSF researchers have revealed two functional archetypes of metastatic cells across 7 different types of brain tumors, each containing both immune and non-immune cell types. Their findings, published the February 17 issue of CELL, provide a potential roadmap for metastatic tumor formation that could be used to design therapies to improve the treatment of metastasized patients.
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Pancreatic Cancer Patient Exceeds Life Expectancy After Complex Whipple Procedure at UCSF
A team of UCSF surgeons devised a successful reconstruction approach during a complex Whipple procedure in a 69-year-old man with locally advanced pancreatic adenocarcinoma.
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Treating Severe Depression with On-Demand Brain Stimulation
UCSF Health physicians have successfully treated a patient with severe depression by tapping into the specific brain circuit involved in depressive brain patterns and resetting them using the equivalent of a pacemaker for the brain.
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Sorting Cancers by “Immune Archetypes” Represents Potential New Approach to Developing Precision Immunotherapies
Using data from over 300 patient tumors, UCSF researchers have described 12 classes of “immune archetypes” to classify cancer tumors. Their findings, published today in CELL, reveal that cancers from different parts of the body are immunologically similar to one another. These classifications provide unique strategies for enhancing each patient’s choice of cancer immunotherapies.
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Gynecologic Cancer and Lynch Syndrome: Identifying Genetic Variants Leads to Precision Treatment
Given the increased risks associated with Lynch syndrome for gynecologic, colon and other cancers, physicians at the UCSF Gynecologic Oncology Center now approach testing, surveillance and treatment based on each patient’s individual genetic risk.
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UCSF-led Study Uncovers Unique Stem Cell Trajectory in Lungs Damaged by COVID-19 and Pulmonary Fibrosis
In a collaborative study between UCSF researchers appearing December 30 in Nature Cell Biology, UCSF researchers Jaymin Kathiriya, PhD, and Chaoqun Wang, PhD, discovered that severe lung injuries can trigger lung stem cells to undergo abnormal differentiation. Drs. Kathiriya and Wang, supervised by Hal Chapman, MD, and Tien Peng, MD, respectively, utilized stem cell organoid models to uncover a novel stem cell pathway that is seen in severely injured lungs from COVID-19 and idiopathic pulmonary fibrosis patients.
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UCSF Case Study: Same-Day Discharge After Pheochromocytoma Removal
San Francisco endocrine surgeon Sanziana Roman, MD, performed a posterior retroperitoneoscopic adrenalectomy (PRA) to remove a pheochromocytoma. This approach enabled the patient to be discharged home within hours of surgery and avoid prolonged hospitalization, thereby minimizing COVID-19 risk.
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UCSF Study Finds 25% of Patients with HPV+ Oropharynx Cancer May Require Chemoradiotherapy After Robotic Surgery
In a nearly 10-year retrospective study involving 136 carefully selected patients with HPV-positive (HPV+) oropharynx cancer, UC San Francisco researchers found that one in four may meet possible indications for adjuvant chemoradiotherapy following transoral robotic surgery (TORS).
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How 3D-Printed, Patient-Specific Models Reduce Orthopaedic Surgery Time and Improve Patient Outcomes
In this interview, Alexis Dang, MD, talks about the benefits to patients and surgeons and the first time he used a 3D-printed, patient-specific model for surgical planning.
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Activating Immune Surveillance Mechanisms Shows Promise for Treating Diabetes and Pulmonary Fibrosis
Researchers at UC San Francisco recently found that activating invariant natural killer T (iNKT) cells eliminated inflammatory senescent cells associated with chronic diseases in vivo. In the study, obese mice showed improved glucose control and mice with pulmonary fibrosis had decreased lung fibrosis and increased survival.
