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International Conference Features UCSF Breast Cancer Experts

Annual Symposium Highlights State-of-the-Art Research and Treatment of Breast Cancer

Breast cancer experts from UCSF Health presented new research and clinical findings at the annual San Antonio Breast Cancer Symposium, the world’s largest and most prestigious breast cancer conference. This year’s meeting was held from Dec. 6 to 10, 2022.

Combining clinical, translational and basic research, the meeting brings together leading breast cancer researchers and clinicians, helping to shape clinical practices and research directions. The international conference returns to an in-person format in San Antonio, Texas, with researchers and physicians attending from over 90 countries.

The mission of the annual conference, which began in 1977 as a one-day regional conference, is for experts in the field of breast cancer research and treatment to share the latest information about the biology, etiology, prevention, diagnosis, and therapy of breast cancer and premalignant breast disease.

The symposium is presented by the Cancer Therapy & Research Center (CTRC) at UT Health Science Center San Antonio, the American Association for Cancer Research (AACR) and Baylor College of Medicine.

This year’s scientific program featured numerous presentations and updates on new and late-breaking data, including diagnostic developments by breast experts at the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC). Here are some highlights:

Panel Session: Thursday, Dec 8, 2 pm to 3 pm CT

Translational Controversies: RIP MTD (maximum tolerated dose). Hope S. Rugo, MD, is a featured speaker on a discussion session panel addressing translational controversies. She will be discussing the rethinking of the concept of the maximum tolerated dose for breast cancer treatment. Rugo is a professor of medicine in the Division of Hematology and Oncology at the Helen Diller Family Comprehensive Cancer Center (HDFCCC) and director of Breast Oncology and Clinical Trials Education.

Spotlight Poster Discussion Session #11: Thursday, Dec. 8, 7 am to 8:15 am CT

Improving Outcome for TNBC: New Directions in Immunotherapy Hope S. Rugo, MD, will chair this session about new treatment strategies for triple negative breast cancer. Discussion topics include enhancing immune response in HER2 negative breast cancer, immunotherapy combinations and corrective markers, and enhancing the effects of immunotherapy in metastatic breast cancer.

Poster Session 3: Wednesday, Dec. 7, 5 pm to 6:15 pm CT

Exposure-adjusted incidence rates (EAIRs) of adverse events (AEs) from the phase 3 TROPiCS-02 study of sacituzumab govitecan (SG) vs treatment of physician’s choice (TPC) in HR+/HER2- metastatic breast cancer (MBC). Rugo is the senior author and presenter of this study which reports on the favorable risk/benefit profile for sacituzumab govitecan (SG) compared with standard chemotherapy in a patient population with limited therapeutic options. View Abstract: P3-07-08

Poster Session 4: Thursday, Dec. 8, 7 am to 8:15 am CT 

Baseline and end-of-treatment biomarkers in patients with PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer from BYLieve Study Cohorts A and B. Rugo is the senior author and presenter of this study which reports the results of a biomarker analysis using paired baseline (Cycle 1 Day 1) and end-of-treatment (EOT) circulating tumor DNA (ctDNA) samples from patients in BYLieve Cohorts A and B. View Abstract: P4-09-12

General Session 5: Friday, Dec. 9, 12 pm to 3 pm

12:30 pm to 12:45 pm CT

Evaluation of anti-PD-1 Cemiplimab plus anti-LAG-3 REGN3767 in early-stage, high-risk HER2-negative breast cancer: Results from the neoadjuvant I-SPY 2 TRIAL. Laura Esserman, MD, MBA, is senior author of this study which is one of several I-SPY 2 study abstracts being reported on at SABCS. This session will address the efficacy of Cemiplimab in a phase 3 neoadjuvant trial. Esserman is a UCSF professor of surgery and radiology, director of the UCSF Breast Care Center and principal investigator of the ISPY 2 trials. View Abstract: GS5-03

12:45 pm to 1 pm CT

Identification of symptoms that are associated with irAEs in the I-SPY clinical trial. Amrita Basu, PhD, is first author and presenter of this study which utilizes an analysis framework to determine symptom clusters that predict the development of irAEs (immune-related adverse events). She will describe specific symptoms presenting early with the development of hypothyroidism and adrenal insufficiency. Basu is an assistant professor of surgery at UCSF. View Abstract: GS5-04

2:15 pm to 2:30 pm CT        

Utility of the 70-gene MammaPrint test for prediction of extended endocrine therapy benefit in patients with early-stage breast cancer in the IDEAL Trial. Laura J. van ’t Veer, PhD, is the senior author and presenter for this session which explores extended endocrine treatment (EET) for MammaPrint Low tumors and the selection of MammaPrint Low patients who benefit of 10-year endocrine treatment. van ’t Veer is the Angela and Shu Kai Chan Endowed Chair in Cancer Research and co-leader of the Breast Oncology Program for the UCSF HDFCCC.View Abstract: GS5-10

2:30 pm to 2:45 pm CT        

Sacituzumab Govitecan (SG) vs Treatment of Physician’s Choice (TPC): Efficacy by Trop-2 Expression in the TROPiCS-02 Study of Patients (Pts) With HR+/HER2–Metastatic Breast Cancer (mBC). Hope S. Rugo, MD, is first author and presenter for this study about new options for treatment of metastatic breast cancer with TROP2 tumor expression. View Abstract: GS5-11

The Year in Review: Saturday, Dec. 10, 8 am to 10 am

In this concluding session of the symposium, Andrei Goga, MD, PhD, will be a featured speaker discussing the latest developments in basic science for breast cancer research. Goga is a professor of cell and tissue biology and co-leader of the Breast Oncology Program at the UCSF HDFCCC.

A complete list of SABCS abstracts is available on the SABCS homepage.